9.0out of 10
The long one — up to 36 hours, or a daily dose that ends the clock-watching
- Onset
- 30–60 minutes, occasionally up to 2 hours
- Lasts
- Up to 36 hours
Medication reviews
ED medications, compared honestly
Head-to-head trials have not shown one PDE5 inhibitor to be dramatically better than another. What separates them is speed, duration, cost, and which side effects you personally get.
8.4out of 10
The default first try — cheap, predictable, heavily studied
- Onset
- 30–60 minutes
- Lasts
- 4–6 hours
7.6out of 10
Avanafil
StendraThe fast one — and the one least likely to tint your vision
- Onset
- As little as 15 minutes
- Lasts
- About 6 hours
7.2out of 10
A close cousin of sildenafil, now mostly a second choice
- Onset
- 30–60 minutes
- Lasts
- 4–8 hours
6.8out of 10
The second-line option that works when pills don't
- Onset
- 5–20 minutes
- Lasts
- 30–60 minutes
5.0out of 10
Udenafil, mirodenafil, lodenafil
Zydena, Mvix, HellevaReal drugs, real evidence, and no legal way to get them here
- Onset
- Udenafil peaks in about 1–1.5 hours; the others are broadly comparable to sildenafil
- Lasts
- Udenafil remains effective up to around 24 hours; mirodenafil and lodenafil are shorter
3.0out of 10
What men were prescribed before Viagra — and why they stopped
- Onset
- Not an on-demand drug — taken on a standing schedule
- Lasts
- Short half-life, hence the three-times-daily dosing
Get emergency help for these
- An erection lasting more than 4 hours — this can cause permanent damage
- Sudden loss of vision or hearing
- Chest pain during or after sex — tell responders you took a PDE5 inhibitor